激活素受體2B抗體供應
『別名』Activin Receptor Type IIB; ACTR-IIB; Activin A receptor type IIB; Activin receptor type 2B; Activin receptor type IIB; Activin receptor type-2B; ActR IIB; ACTR-IIB; ActRIIB; ACVR 2B; ACVR2B; AVR2B_HUMAN; HTX4; MGC116908.
『濃度』1mg/1ml
『規格』0.2ml/200μg
『抗體來源』Rabbit
『克隆類型』polyclonal
『交叉反應』Human, Mouse, Rat, Dog, Pig, Cow, Sheep
『產品類型』一抗
『研究領域』細胞生物 信號轉導 干細胞 生長因子和激素 激酶和磷酸酶 細胞表面分子
『蛋白分子量』predicted molecular weight: 56kDa
『性狀』Lyophilized or Liquid
『免疫原』KLH conjugated synthetic peptide derived from human ACVR2B/ACTR-IIB
『亞型』IgG
『純化方法』affinity purified by Protein A
『儲存液』Preservative: 15mM Sodium Azide, 激活素受體2B抗體供應Constituents: 1% BSA, 0.01M PBS, pH 7.4
『產品應用』WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
『保存條件』Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
『產品介紹』Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex (1). Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B) (1-6). Both receptor types are highly expressed in brain (5). The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion (5,6).
Function : On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Subunit : Forms an activin receptor complex with activin type II receptors such as ACVR1B. Interacts with VPS39.
Subcellular Location : Cell membrane; Single-pass type I membrane protein (By similarity).
Post-translational modifications : Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity.
DISEASE : Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4) [MIM:613751]. A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy type 4 include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver.
Similarity : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
TGFB receptor subfamily.
Contains 1 protein kinase domain.
Database links : UniProtKB/Swiss-Prot: Q13705.3
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